Gene therapy and stem cell s-mediated periodontal and craniofacial bone regeneration
We have established a standardized system for assessing the osteogenic activity of BMP gene transduced mouse embryonic fibroblast by using adenovirus system in mice. We found exploited the potential of gene therapy to express combinations of interacting genes. We examined the ability of combinations of adenoviruses expressing BMP2, 4, 7 and RUNX2 in fibroblast cells and mesenchymal stem cells.
Additional studies are focusing on:
1. Identifying and developing new tissue engineering biomaterials and scaffolds in animal models.
2. Developing novel genetically modified stem cell mediated bone constructs for periodontal and craniofacial bone regeneration
3. Using animal models to assess short- and long-term function of engineered bone tissue constructs in vivo
Disciplines: Oral Biology
Student Skill-Set Needed: Biomedical Laboratory experience desirable but not essential.
Compensation: Academic Credit, Volunteer, Work Study
Available: Fall, Spring, Summer
For further information on this opportunity, or to apply, contact:
Faculty Member: Shuying Yang
Department: Oral Biology
Office: B36 Foster Hall, 3435 Main Street