Estrogen activates estrogen receptors (ER) by directly binding to its ligand binding domain and mediates a cascade of cellular signaling events. Various endocrine disrupting chemicals (EDC) including alkylphenols, bisphenols, diethylstilbestrol (DES) mimic estrogen action by bind directly to the ligand binding domain of ER. While these EDCs have the required pharmacophore to induce agonist conformation of ER, many EDCs that are currently classified as weak estrogens, produce considerable endocrine damage even at low exposure. Plasticizers, alkoxybisphenols and phthalate esters, do not share estrogen pharmacophore but are probably misclassified as compounds binding to ER-LBD. In this project the student reseacher will employ integrated in silico and in vitro structure-activity analyses of EDCs and their ability to modulate estrogen receptor activity by acting on a non-ligand binding site.
Student Skill-Set Needed: Curiosity and keen interest in exploring the possibilities!
Compensation: Academic Credit, Volunteer, Work Study
Available: Fall, Spring, Summer
For further information on this opportunity, or to apply, contact:
Faculty Member: Rajendram Rajnarayanan
Title: Assistant Professor
Department: Pharmacology And Toxicology