Student working on a research project.

Molecular Pathogenesis Of Hereditary Demyelinating Neuropathies

Myelin surrounds large axons and permits rapid conduction of signals. It is formed by oligodendrocytes in the central nervous system, and Schwann cells in the peripheral nervous system. During development, these cells migrate with the axons that they will myelinate, and depend on those same axons for appropriate signals to survive and differentiate. Myelin-forming glia coordinately express a unique set of genes encoding myelin structural proteins, and enzymes that synthesize myelin lipids-this coordination is in large part transcriptionally-mediated. Given the unique three dimensional transformation of the cell required for myelination, many of the involved proteins include adhesion among their functions. Therefore, our projects include studies of transcriptional regulation, axonal signals to myelinating glia, the role of adhesion in myelination and the characterization of animals models of human demyelinating diseases.

Research Project Information

Disciplines: Molecular Biology, Genetics, Biochemistry, Neuroscience
Student Skill-Set Needed: ***POSITION CURRENTLY FILLED*** Coursework in Biology or Chemistry
Compensation: Academic Credit, Salary / Stipend, Volunteer
Available: Fall, Spring, Summer


For further information on this opportunity, or to apply, contact:

Faculty Member: Lawrence Wrabetz
Title: Professor
Department: Biochemistry
Office: NYS Center Of Excellence, 701 Ellicott St, Buffalo, NY 14203
Phone: 716-881-8913