Myelin is vital for transmission of neural signals in brain. Much effort is currently being
expended for therapeutic interventions capable of halting myelin damage and promoting
repair. However, a major hindrance to translating basic science results to clinical
practice is the lack of a well-defined, standard means for quantifying
demyelination and remyelination in vivo.
Our lab aims to take steps towards addressing this limitation. First, we will create a
novel animal model of demyelination, and then acquire an in vivo dataset with all
available individual MRI sequences. This work will allow us to evaluate whether
candidate MRI myelin imaging techniques are sensitive and specific. Next, we aim to
compare head-to- head the accuracy and precision of current MRI methods. And finally,
determine the best multi-modal combination of available methods. This will produce an
“ideal” classification technique that will establish the maximum myelin density prediction
power for available MRI.
With the CTRC’s 9.4T animal MRI scanner and laboratory animal facilities, we are
uniquely positioned to undertake this work. The successful implementation of a clinically
viable MRI measurement for myelin with a new standard mouse model for differentiation
of myelin changes from inflammatory changes. This will be useful both for the present
work and for others evaluating any future advances in myelin imaging.
Student Skill-Set Needed: experience in stereotactic surgeries, rodent handling, and rodent injections.
Compensation: Academic Credit
Available: Fall, Spring, Summer
For further information on this opportunity, or to apply, contact:
Faculty Member: Dr. R. Zivadinov M.D. PhD
Department: Medicine And Biomedical Sciences
Office: D2 BGH, 100 High Street, Buffalo , NY14203