Student working on a research project.

Nuclear Functions Of Actin And Myosins

Over the last several years the identification and functional characterization of the motorproteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now well-accepted that actin as well as various myosins are engaged in RNA processing and transport, chromatin remodeling, and transcription by RNA polymerase I, II and III. Several research projects are available that will analyze the function and regulation of nuclear actin and nuclear myosins, such as analysis of transcription by RNA polymerase II. We use in vitro as well as in vivo transcription assays to understand how exactly actin and myosins are involved in this specific process. Other research projects are directed at understanding the regulation of nuclear actin and myosins during oxidative stress in cardiac diseases such as the ischemic heart, in cancer, as well as in neuronal diseases such as Alzheimer's.

Research Project Information

Disciplines: Biochemistry, Biological Sciences, Molecular And Cellular Biology
Student Skill-Set Needed: Prior experience in a laboratory setting is helpful but not necessary. We will train as required
Compensation: Academic Credit, Volunteer, Work Study
Available: Fall, Spring, Summer
Website: http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=whofmann

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: Wilma A. Hofmann
Department: Physiology And Biophysics
Office: 517 BRB
Phone: 829-3290
Email: whofmann@buffalo.edu