Student working on a research project.

The Role Of Calcium Channels In The Development And Function Of Glial Cells

***POSITION CURRENTLY FILLED*** Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells. The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Therefore, understanding the role of ion channels on astrocyte development and function could lead to novel approaches to intervene in neurodegenerative diseases and brain injuries in which inflammation and astrogliosis play a detrimental role.

Research Project Information

Disciplines: Biology Chemistry
Student Skill-Set Needed: ***POSITION CURRENTLY FILLED*** Coursework in Biology or Chemistry
Compensation: Academic Credit, Salary / Stipend, Volunteer, Work Study
Available: Fall, Spring, Summer
Website: http://hjkri.buffalo.edu/paez.html

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: Pablo M. Paez
Title: Assistant Professor
Department: Pharmacology And Toxicology
Office: NYS Center Of Excellence, 701 Ellicott St, Buffalo, NY 14203
Phone: 716-881-7823
Email: ppaez@buffalo.edu