Student working on a research project.

Understanding The Mechanisms Of DNA Mismatch Repair

Errors in DNA replication occur at the replication fork, leading to misincorporation events, which are potentially mutation. The mismatch repair system recognizes these errors and targets them for repair. In the absence of mismatch repair, mutations rates are significantly elevated. Mutations in the mismatch repair system are associated with many sporadic cancers as well as hereditary non-polyposis colorectal cancer (HNPCC), an hereditary cancer syndrome. We are particularly interested in the recognition step of mismatch repair, that is how mispairs are recognized and how that translates to repair through the recruitment of downstream factors. We use a combination of genetic, biochemical and biophysical approaches to understand this pathway, which is critical in maintaining genome stability.

Research Project Information

Disciplines: Biochemistry, Molecular Biology, Genetics, Tumorigenesis
Student Skill-Set Needed: Background in Biology
Compensation: Academic Credit, Volunteer, Work Study
Available: Fall, Spring, Summer
Website: http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=jsurtees

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: Jennifer A. Surtees
Title: Assistant Professor
Department: Biochemistry
Office: 619 Biomedical Research Building
Phone: 716 829-6083
Email: jsurtees@buffalo.edu