Magnetic resonance imaging (MRI) is a clinically important diagnostic procedure, with about half of MRI scans using contrast agents in order to better image differences in tissue. Nearly all clinically used contrast agents contain gadolinium, yet a large proportion of patients in the US population (ca 30%) are considered at risk for being given gadolinium contrast agents. The proposed research entails the development of iron MRI contrast agents as alternatives for gadolinium. These iron based MRI contrast agents function in the same manner as do the gadolinium agents and are synthesized as coordination complexes that contain macrocyclic ligands. Students will participate by synthesizing and characterizing Fe(III) complexes, making measurements of water proton relaxation by NMR spectroscopy, fitting of the data, and by preparation of samples for MRI studies.
Disciplines: physics, biomedical engineering
Student Skill-Set Needed: courses in general and organic chemistry. Inorganic chemistry is preferred but not necessary.
Compensation: Academic Credit
Available: Fall, Spring, Summer
For further information on this opportunity, or to apply, contact:
Faculty Member: Janet R Morrow
Office: 526 Natural Sciences Complex, Chemistry