Student working on a research project.

Exosome-Mediated MRI Contrast Agent Delivery Across The Blood Brain Barrier

Upon inception, Magnetic Resonance Imaging has relied on specific contrast agents to improve the visibility of internal body structures. Gadovist, a gadolinium-based MRI contrast agent, is a model compound for contrast enhancement and is commonly used in visualizing tumors and pathology in the body. While exceptional in performing contrast enhancement, Gadovist is hydrophilic and therefore extremely limited in its accessibility to the brain via the Blood Brain Barrier and requires innovative methods for assistance. Although many techniques exist in transporting Gadovist through the blood brain barrier, these techniques are highly invasive and result in damage or degradation of tissue. In order to extend our boundaries of current knowledge regarding neurological diseases, the Buffalo Neuroimaging Analysis Center’s Preclinical Unit is currently investigating non-invasive methods of transferring Gadovist through the Blood Brain Barrier with the use of minuscule membrane vesicle transporters.

Research Project Information

Disciplines: Neurology, Physics, Biostatistics, Neuroscience, Biology, Neuroimaging, Radiology
Student Skill-Set Needed: Experience in cell culturing, brain segmentation, rodent handling, and rodent injections.
Compensation: Academic Credit
Available: Spring
Website: http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=rz4

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: Dr. Robert Zivadinov
Title: Professor
Department: Medicine And Biomedical Sciences
Office: 100 High Street; D-2; Buffalo, NY 14203
Phone: 7168593579
Email: rz4@buffalo.edu