Student working on a research project.

Protein Arginine Methylation In Cryptococcus Neoformans Pathogenesis

Cryptococcus neoformans is a pathogenic fungus that is estimated to kill over 500,000 people per year, mostly as a result of HIV co-infection. Protein arginine methylation is a post-translational modification that can alter the function of proteins and increase the functional proteome. Our preliminary data suggests that the protein arginine methyltransferase 5, Rmt5, is important for maintenance of morphology during infection, and impacts the production of phagocytosis resistant titan cells. In addition, a cell integrity signaling is defective in an rmt5 deletion mutant. The student will utilize biochemical and cell biological techniques to investigate the role of Rmt5 in regulation of cell integrity signaling and titan cell production in C. neoformans.

Research Project Information

Disciplines: Microbiology, Molecular Biology, Biochemistry
Student Skill-Set Needed: Ability to work independently, Understanding of molarity and basic chemistry, Willingness to follow laboratory guidance and safety regulations, Ability to focus with attention to detail
Compensation: Academic Credit, Volunteer, Work Study, Academic Credit, Volunteer, Work Study, MIC 301, General Chemist
Available: Fall, Spring, Summer
Website: http://medicine.buffalo.edu/content/medicine/faculty/profile.html?ubit=jcp25

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: John Panepinto
Title: Assistant Professor
Department: Microbiology And Immunology
Office: 117 BRB, South Campus
Phone: 716-829-2090
Email: jcp25@buffalo.edu