Student working on a research project.

CYP3A5 Polymorphisms And Pharmacokinetics Of Protease Inhibitors In Patients With HIV Infection

***POSITION CURRENTLY FILLED*** This study will examine the pharmacokinetics of HIV-1 protease inhibitors (PIs) lopinavir (LPV) and atazanavir (ATV) and the extent to which greater understanding of pharmacogenetics may enhance efficacy and alleviate drug toxicity. We will investigate single nucleotide polymorphisms (SNPs) in HIV-infected patients and evaluate their relationship to antiretroviral (ARV) plasma concentrations as a means of individualizing treatment based on race/ethnicity. Project goal: The objective of this project is to determine the frequency of CYP3A5 polymorphism at the 6986A>G locus among different racial/ethnic groups, and to examine the relationship of this polymorphism to trough plasma concentrations of ATV and LPV in substance abusers versus non-substance abusers. CYP3A5 plays an important role in drug metabolism of a wide variety of substrates such as HIV-1 PIs. CYP3A5 expression is highly polymorphic and enzyme activity varies among different populations depending on their racial ancestry. The main limitation of PIs is the interpatient variability in their pharmacokinetics (PK) which results primarily from interindividual variation in activity of cytochrome CYP3A. The HIV-1 PIs, ATV and LPV, are widely used in potent ARV therapy. Thus, the central hypothesis of this study is that CYP3A5 genotype is correlated with the extent of drug metabolism of specific ARV therapy and genotype-based therapeutic drug monitoring may be beneficial for patients by facilitating the attainment of target plasma ARV concentrations.

Research Project Information

Disciplines: Pharmacy Practice
Student Skill-Set Needed: ***POSITION CURRENTLY FILLED*** This study involves 277 subjects who have been enrolled based on a protocol approved by the institutional review boards at University at Buffalo, Montefiore Medical Center, University of Rochester, University of Miami
Compensation: Salary / Stipend

Contact

For further information on this opportunity, or to apply, contact:

Faculty Member: Lauren Wehner, Dr. Gene Morse
Title: Project Staff Assistant
Affiliation: NYS Center Of Excellence In Bioinformatics And Life Sciences
Department: Translational Pharmacology Research Core
Office: 701 Ellicott Street
Phone: 716-881-7512
Email: lawehner@buffalo.edu