We are studying the role of protein methylation in regulating growth using yeast as a model system.We found that deleting a gene that is required for all cellular methylation markedly inhibitied growth. We are focusing on three protein methyltransferases(MTases) to account for the effect on growth using gene deletion mutants of each and in combination .These MTases may work by affecting histones(chromatin),translation,and the cell cycle. Protein methylation has already been implicated in cancer;i.e. this work has medical significance.
Student Skill-Set Needed: Any research experience would be helpful, but we will teach all required skills.
Compensation: Academic Credit
Available: Fall, Spring, Summer
For further information on this opportunity, or to apply, contact:
Faculty Member: Murray J. Ettinger
Office: 140 Farber Hall